TRIM15 drives chondrocyte senescence and osteoarthritis progression.

Zhuang Li, Weituo Zhang, Xiao Ying Wei, Jun Zheng Hu, Xinyue Hu, Haoyang Liu, Jun Lu, Shuying Shen, Ming-Liang Ji

Center of Joint and Sports Medicine, Orthopedics Department, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.Center of Joint and Sports Medicine, Orthopedics Department, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China. · pubmed

Paper

Abstract

Osteoarthritis (OA) is a prevalent joint disease characterized by pain, disability, and loss of physical function, posing a challenge to public health. However, molecular mechanisms of OA pathogenesis have not been fully described. We report that tripartite motif containing 15 (TRIM15) is a regulator in chondrocyte senescence and OA. Our study revealed heightened expression of TRIM15 in chondrocytes of senescent cartilage from patients with OA and in aged wild-type mice. Using gain- and loss-of-function studies, we found that TRIM15 facilitated human chondrocyte senescence. Conditional deletion of

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Research summary

TRIM15 is identified as a regulator of chondrocyte senescence and osteoarthritis progression. The study addresses the molecular mechanisms underlying chondrocyte senescence, which is a key factor in aging and age-related diseases, thus contributing to the understanding of the aging process.

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