Rosuvastatin restores liver tissue-resident NK cell activation in aged mice by improving mitochondrial function.

Johnny Amer, Ahmad Salhab, Rifaat Safadi

Liver Institute, Hadassah-Hebrew University Hospital, Jerusalem, Israel. Electronic address: [email protected]. · pubmed

Paper

Abstract

Aging has an impact on Natural Killer (NK) cells surveillance against tumors and infections. Our study aims to assess the aging effects on metabolic and mitochondrial markers influencing NK cell activity.

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Research summary

Rosuvastatin improves mitochondrial function, leading to enhanced activation of liver tissue-resident NK cells in aged mice. This study addresses the impact of aging on immune function, which is a critical aspect of longevity research.

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