Physical training reduces cell senescence and associated insulin resistance in skeletal muscle.

Agnieszka Podraza-Farhanieh, Rosa Spinelli, Federica Zatterale, Annika Nerstedt, Silvia Gogg, Matthias Blüher, Ulf Smith

Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden. · pubmed

Paper

Abstract

Cell senescence (CS) is a key aging process that leads to irreversible cell cycle arrest and an altered secretory phenotype. In skeletal muscle (SkM), the accumulation of senescent cells contributes to sarcopenia. Despite exercise being a known intervention for maintaining SkM function and metabolic health, its effects on CS remain poorly understood.

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Research summary

Physical training reduces cell senescence and associated insulin resistance in skeletal muscle. The paper addresses the root cause of aging by exploring how exercise can mitigate cellular senescence, which is a significant factor in age-related decline in muscle function and metabolic health.

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