Mito-Modulatory Medication Use and Skeletal Muscle Bioenergetics Among Older Men and Women: the Study of Muscle, Mobility and Aging.

Howard J Phang, Jaclyn Bergstrom, Rabia S Atayee, Laura A Hart, Peggy M Cawthon, Terri Blackwell, Philip A Kramer, Giovanna Distefano, Erin E Kershaw, Steven R Cummings, Anthony J A Molina

Department of Medicine, University of California San Diego; La Jolla, CA, USA.Department of Medicine, University of California San Diego; La Jolla, CA, USA. · pubmed

Paper

Abstract

The potential impacts of drug-induced modulation of mitochondrial function in humans remain unclear despite the high prevalence of "mito-modulatory" medication use among older adults. While these medications, such as statins and metformin, have undergone extensive characterization of their effects on mitochondrial function in vitro, the effects in humans are far more complex and poorly understood.

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Research summary

The paper investigates the effects of mito-modulatory medications on mitochondrial function in older adults. This research is relevant as it explores potential interventions that could influence the biological mechanisms of aging and improve healthspan.

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