Epimedii Folium and Ligustri Lucidi Fructus synergistically delay renal aging through AMPK/ULK1/Bcl2L13-mediated mitophagy.

Yuting Long, Yuman Li, Zaina Ma, Yonghao Xie, Hui Zhao, Minyu Zhang, Renhui Liu

School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. · pubmed

Paper

Abstract

The root of aging is attributed to kidney essence insufficiency and gradual loss of kidney function. The combination of Epimedii Folium and Ligustri Lucidi Fructus (ELL) is traditionally recognized to tonify kidney yin and yang and has significant efficacy in delaying aging and aging-related diseases, but little is known about the exact mechanism.

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Research summary

The paper claims that the combination of Epimedii Folium and Ligustri Lucidi Fructus can delay renal aging through a specific cellular mechanism involving mitophagy. This research is relevant as it addresses potential interventions targeting the underlying mechanisms of aging, specifically in the context of kidney function.

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