The role of genetic/epigenetic factors and microenvironment in hematopoietic stem cell ageing.
Abstract
Hematopoietic stem cells (HSCs) ageing is a phenomenon described by reduction in self-renewal capacity, compromised homing, a bias towards myeloid differentiation, and defective reconstitution function. The molecular mechanisms of HSCs ageing have been investigated by several groups. In a broad classification, the underlying causes can be grouped into the intrinsic factors and those related to the microenvironment. Determination of the exact mechanism of HSCs ageing and detailed molecular events during its initiation and progression will help in the establishment of novel therapies for the treatment or prevention of ageing-related hematopoietic disorders. This review offers an overview of genetic and epigenetic causes of HSCs ageing. The findings of these investigations paved the way for design of novel strategies for rejuvenation of HSCs.
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Research summary
The paper discusses the genetic and epigenetic factors contributing to hematopoietic stem cell ageing and potential rejuvenation strategies. This research is relevant as it addresses intrinsic mechanisms of aging and aims to develop therapies that could mitigate age-related decline in stem cell function.
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