Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications.

Yimin Li, Chongyang Wang, Xiaoxia Fu, Dan Wu, Chenyang He, Wenyu Dai, Xiaoyang Yue, Zhenhuan Luo, Jing Yang, Qin-Li Wan

Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, China; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, 510632, Guangdong, China.Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, China; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, 510632, Guangdong, China. · pubmed

Paper

Abstract

Mitochondrial hormetic oxidative stress (mtHOS) is crucial in physiology and disease; however, its effects on epigenetic inheritance and organism fitness across generations remains elusive. Utilizing the C. elegans as a model, we elucidate that parental exposure to mtHOS not only elicits a lifespan extension in the exposed individuals but also confers this longevity advantage to the progeny through the transgenerational epigenetic inheritance (TEI) mechanism. This transgenerational transmission of lifespan prolongation depends on the activation of the UPR

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Research summary

Parental exposure to mitochondrial hormetic oxidative stress can extend lifespan in both exposed individuals and their progeny through transgenerational epigenetic inheritance. This study addresses mechanisms that may influence longevity and lifespan extension, making it relevant to the field of aging research.

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