Epigenetic and accelerated age in captive olive baboons (

Sarah J Neal, Shannon Whitney, Soojin V Yi, Joe H Simmons

The University of Texas MD Anderson Cancer Center, Michale E. Keeling Center for Comparative Medicine and Research, National Center for Chimpanzee Care, TX 78602, USA. · pubmed

Paper

Abstract

Epigenetic age, estimated by DNA methylation across the genome, reflects biological age. Accelerated age (i.e., an older methylation age than expected given chronological age) is an accepted aging biomarker in humans, showing robust associations with deleterious health outcomes, longevity, and mortality. However, data regarding age acceleration in nonhuman primates (NHPs), and relationships between NHP epigenetic age and behavioral indicators of aging, such as walking speed and fine motor performance, are sparse. We measured DNA methylation of 140 captive olive baboons (

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Research summary

The paper claims to investigate the relationship between epigenetic age and behavioral indicators of aging in olive baboons. This research is relevant as it explores biological aging mechanisms in nonhuman primates, which could provide insights into the root causes of aging and longevity.

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