Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice.

Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos

School of Medicine, University of Crete, Heraklion, Greece.School of Medicine, University of Crete, Heraklion, Greece. · pubmed

Paper

Abstract

The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms remain elusive. This study delves into the previously unexplored role of autophagy in maintaining CNS myelin during aging. We generated the transgenic mouse line plpCre

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Research summary

Disruption of oligodendroglial autophagy leads to myelin deficits and cognitive decline in aged mice. The study addresses the mechanisms of myelin degeneration in the aging CNS, which is a critical aspect of understanding and potentially mitigating age-related cognitive decline.

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