Interplay of transposable elements and ageing: epigenetic regulation and potential epitranscriptomic influence.

Raquel García-Vílchez, Diana Guallar

Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Barcelona Avenue s/n, Santiago de Compostela, A Coruña 15782, Spain. Electronic address: https://twitter.com/@raquelgarcv.Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Barcelona Avenue s/n, Santiago de Compostela, A Coruña 15782, Spain. Electronic address: https://twitter.com/@raquelgarcv. · pubmed

Paper

Abstract

Transposable elements (TEs) are mobile elements, which have been crucial for mammalian genome evolution and function. Their activity, which influences genomic stability, gene expression and chromatin state, is tightly regulated by complex mechanisms. This review examines recent findings on TE regulation and the dynamics and connection during the ageing process. Here, we explore the interplay between chromatin state, DNA, RNA, and histone modifications in controlling TE activity, with a special emphasis in elucidating the emerging role of epitranscriptomic modifications in TE regulation. Additionally, we analyse the connection between TE activation and ageing, with the perspective for future research that could reveal novel targets for alleviating physiological and pathological ageing and age-related diseases.

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Research summary

The paper discusses the regulation of transposable elements and their connection to the ageing process. This research is relevant as it explores potential mechanisms that could influence the root causes of ageing and age-related diseases.

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