Deciphering Novel Communication Patterns in T Regulatory Cells From Very Old Adults.

Tegan McTaggart, Jing Xuan Lim, Katie J Smith, Bronagh Heaney, David McDonald, Gillian Hulme, Rafiqul Hussain, Jonathan Coxhead, Derek A Mann, Avan A Sayer, Antoneta Granic, Shoba Amarnath

Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK.Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK. · pubmed

Paper

Abstract

Regulatory T cells (Tregs) are important in maintaining tolerance and are key players in immunity. In aging, increased Treg function along with low-grade inflammation has been reported. This dichotomy of enhanced Treg function along with inflammation highlights the importance of understanding Treg biology and communication patterns in the very old. In this proof-of-concept study, we demonstrate that aged Tregs (85 years) do not significantly communicate with CD4

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Research summary

Aged Tregs do not significantly communicate with CD4 T cells. This study is relevant as it explores the biology of T regulatory cells in the context of aging, which could provide insights into immune function and tolerance in very old adults, potentially informing strategies for longevity and age-related immune dysfunction.

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