Effects of aerobic and resistance training on bone, muscle hypertrophy and inflammation in OVX mice.

Luciana Botelho Ribeiro, Pedro Gustavo Machado, Juliana Cristina Reis-Canaan, Ivam Moreira de Oliveira Júnior, Natália Oliveira Bertolini, Soraia Macari, Cândido Celso Coimbra, Luciano José Pereira

Graduate Program in Veterinary Sciences, Universidade Federal de Lavras (UFLA), Lavras, MG, Brazil.Graduate Program in Veterinary Sciences, Universidade Federal de Lavras (UFLA), Lavras, MG, Brazil. · pubmed

Paper

Abstract

Bone loss is common with aging, particularly due to reduced sex hormones, as seen in menopause. While physical training is a known non-pharmacological therapy for osteopenia and sarcopenia, few studies compare resistance and aerobic protocols, especially with systemic inflammatory markers. This study evaluated the effects of aerobic and resistance training on physical performance, femoral trabecular bone quality (micro-computed tomography), serum inflammatory markers (IL-1β, IL-6, TNF-α, IL-10) and gastrocnemius muscle area in ovariectomized (OVX) female mice.

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Research summary

The paper claims that both aerobic and resistance training can positively affect bone quality, muscle hypertrophy, and inflammation in OVX mice. This research is relevant as it explores non-pharmacological interventions that may address age-related conditions such as osteopenia and sarcopenia, which are significant contributors to aging and longevity.

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