Untargeted metabolomics reveals homogeneity and heterogeneity between physiological and pathological ovarian aging.

Lihua Zeng, Yunyi Liang, Lizhi Huang, Zu'ang Li, Manish Kumar, Xiasheng Zheng, Jing Li, Songping Luo, Ling Zhu

Department of Gynecology, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.Department of Gynecology, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. · pubmed

Paper

Abstract

Ovarian aging is the main cause of reduced reproductive life span, yet its metabolic profiles remain poorly understood. This study aimed to reveal the metabolic homogeneity and heterogeneity between physiological and pathological ovarian aging.

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Research summary

This study reveals the metabolic profiles associated with physiological and pathological ovarian aging. The research addresses the biological mechanisms underlying ovarian aging, which is directly related to reproductive longevity and age-related decline in fertility.

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