IL-8 as a Causal Link Between Aging and Impaired Influenza Antibody Responses in Older Adults.

Huy Quang Quach, Krista M Goergen, Diane E Grill, Inna G Ovsyannikova, Gregory A Poland, Richard B Kennedy

Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA. · pubmed

Abstract

Antibody responses to MF59-adjuvanted (MF59Flu) and high-dose (HDFlu) influenza vaccines have been well-characterized in older adults, yet corresponding cellular immune response data remain limited.

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Research summary

The paper claims that IL-8 is a causal link between aging and impaired influenza antibody responses in older adults. This research addresses the underlying mechanisms of immune response decline with age, which is pertinent to understanding aging and potential interventions.

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