Non-invasive MRI measurements of age-dependent in vivo human glymphatic exchange using magnetization transfer spin labeling.
Abstract
The water exchange between brain parenchyma and cerebrospinal fluid (CSF) is considered to be responsible for glymphatic clearance of solutes and metabolic wastes from the brain, including amyloid-β, a biomarker in neurodegeneration. Despite the potential significance, no noninvasive technique for in vivo measurement of parenchyma-CSF water exchange has been demonstrated in humans, capable of investigating age-related changes in glymphatic clearance.
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Research summary
The paper claims to demonstrate a non-invasive MRI technique for measuring age-dependent glymphatic exchange in humans. This research is relevant as it addresses the mechanisms of glymphatic clearance, which is linked to neurodegenerative processes and could provide insights into age-related cognitive decline.
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