Cordycepin's therapeutic potential: in vivo transport, transbilayer diffusion and anti-aging effects.

Xiaoliang Zhang, Sijia Wu, Qihan Huang, Shubo Jing, Pang Yong, Ling Zhang, Hong Zhuang

College of Food Science and Engineering, Jilin University, Jilin, China.College of Food Science and Engineering, Jilin University, Jilin, China. · pubmed

Paper

Abstract

Cordycepin (3'-deoxyadenosine) is a bioactive compound known for its numerous beneficial properties, including antioxidant, anti-aging and antitumor effects. Despite its promising therapeutic potential, the in vivo transport mechanisms of cordycepin remain inadequately understood. Previous studies have highlighted its biological activity, but there is limited information regarding its transport and distribution, as well as how it interacts with biological systems to exert these effects. The present study explored the transport mechanisms of cordycepin, specifically its interaction with bovine serum albumin (BSA) transporters and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes, and assessed its anti-aging effects through cellular experiments.

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Research summary

The paper investigates the transport mechanisms of cordycepin and its anti-aging effects. The focus on anti-aging effects and understanding transport mechanisms contributes to the broader understanding of potential interventions in the aging process.

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