Small extracellular vesicles from young adipose-derived stem cells ameliorate age-related changes in the heart of old mice.

Jorge Sanz-Ros, Javier Huete-Acevedo, Cristina Mas-Bargues, Nekane Romero-García, Mar Dromant, Michel van Weeghel, Georges E Janssens, Consuelo Borrás

MiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, Valencia, Spain.MiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, Valencia, Spain. · pubmed

Paper

Abstract

Aging entails a progressive decline in physiological functions, elevating the risk of age-related diseases like heart failure or aortic stenosis. Stem cell therapies, especially those that use paracrine signaling, can potentially mitigate the adverse effects of aging.

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Research summary

Small extracellular vesicles from young adipose-derived stem cells can improve age-related cardiac changes in older mice. This research addresses the underlying mechanisms of aging and explores potential therapeutic strategies to mitigate age-related physiological decline.

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