Hydrogen sulfide attenuates oxidative stress-induced cellular senescence via the Sirt3/SOD2 signaling pathway in chronic obstructive pulmonary disease.

Sha Liao, Dian Chen, Huanyu Long, Simin Jiang, Jing Fan, Shurun Li, Yongfen Qi, Lixiang Xue, Yanling Ding, Yahong Chen

Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China. · pubmed

Paper

Abstract

Senescence significantly participates in shaping the pathobiological process underlying chronic obstructive pulmonary disease (COPD). Currently, the mechanisms underlying the anti-aging effects within COPD of hydrogen sulfide (H2S) are not fully illustrated.

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Research summary

Hydrogen sulfide reduces oxidative stress-induced cellular senescence in COPD through the Sirt3/SOD2 signaling pathway. The paper addresses mechanisms that may contribute to cellular aging processes, which is pertinent to longevity research.

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