Fndc5/irisin mediates the benefits of aerobic exercise intervention on aging-associated sarcopenia in mice.

Yuxia Ma, Yi Liu, Jiachuang Zheng, Zhixia Zheng, Jingjing Li

Department of Geriatric Medicine, Longgang Central Hospital of Shenzhen, No.6082 Longgang Avenue, Longgang District, Shenzhen, 518116, Guangdong, China. [email protected] of Geriatric Medicine, Longgang Central Hospital of Shenzhen, No.6082 Longgang Avenue, Longgang District, Shenzhen, 518116, Guangdong, China. [email protected]. · pubmed

Paper

Abstract

In this study, 24-month-old (aged) mice were used as a naturally occurring model of aging-associated sarcopenia, while 2-month-old (young) mice served as the normal control. Six weeks of treadmill training was employed as an aerobic exercise intervention. The mRNA and protein levels of fibronectin type III domain-containing protein 5 (Fndc5/irisin), MuRF1, and Atrogin-1 in gastrocnemius muscles were analyzed using qRT-PCR and Western blot. Oxidative stress was assessed using relevant detection kits. Skeletal muscle function was evaluated through the four-paw hanging test, rotarod test, grip strength assay, and measurements of quadriceps, tibialis anterior, and gastrocnemius muscle mass.

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Research summary

The paper claims that Fndc5/irisin mediates the benefits of aerobic exercise on aging-associated sarcopenia in mice. This research is relevant as it explores a potential mechanism (Fndc5/irisin) that could address the root causes of sarcopenia, a condition associated with aging, thereby contributing to our understanding of aging and potential interventions.

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