microRNA-34 family: A multifunctional miRNA family.

Chen Wang, Ximei Yuan, Yuejun Fu

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi Key Laboratory of Biotechnology, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

MicroRNAs are endogenous non-coding small RNAs composed of about 22 nucleotides, which are widely found in eukaryotic cells and regulate gene expression at the post-transcriptional level through complementary pairing with target genes, leading to mRNA degradation or translation inhibition. MiR-34 family is a highly conserved miRNA family during evolution. Recent studies have found that members of the miR-34 family are involved in regulating biological processes such as aging, ciliogenesis, and immunity. To have a more comprehensive understanding of miR-34 family, this paper reviewed the functional evolution of miR-34 family, and provided a reference for further research on the related functions of miR-34.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper reviews the multifunctional roles of the microRNA-34 family in biological processes related to aging. The involvement of miR-34 in regulating aging processes suggests potential implications for understanding the mechanisms of longevity.

Author of this paper? Send a correction.