Heat treatment activates futile calcium cycling in brown adipose tissue to modulate energy metabolism and alters gut microbiota in C57BL/6 mice.

Rong Fan, Galaxie Story, Judy Kim, Zhuoheng Li, Sean T Bannon, Hyunji Cho, Ravi Ranjan, Young-Cheul Kim, Gwenael Layec, Soonkyu Chung

Department of Nutrition, University of Massachusetts, Amherst, Massachusetts, USA.Department of Nutrition, University of Massachusetts, Amherst, Massachusetts, USA. · pubmed

Paper

Abstract

Aging decreases the metabolic rate and increases the risk of metabolic diseases, highlighting the need for alternative strategies to improve metabolic health. Heat treatment (HT) has shown various metabolic benefits, but its ability to counteract aging-associated metabolic slowdown remains unclear. This study aimed to investigate the impact of whole-body HT on energy metabolism, explore the potential mechanism involving the heat sensor TRPV1, and examine the modulation of gut microbiota.

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Research summary

Heat treatment activates futile calcium cycling in brown adipose tissue, modulating energy metabolism and gut microbiota. This study addresses mechanisms that could counteract aging-associated metabolic decline, which is directly relevant to longevity research.

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