Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin.

Hanlin Tu, Yingliang Shi, Yi Guo, Zhongyang Zou, Yuyan He, Jing Zhou, Sangang He, Guoliang Sa

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China. · pubmed

Paper

Abstract

Alterations in intercellular communication driven by cellular senescence constitute an important factor in skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates in intercellular communication; however, the relationship between cellular senescence and migrasomes remains unreported.

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Research summary

Young fibroblast-derived migrasomes can alleviate keratinocyte senescence and enhance wound healing in aged skin. This research addresses cellular senescence, a fundamental aspect of aging, and explores a potential mechanism for improving skin health in the context of aging.

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