Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging.

Estefanía Díaz-Del Cerro, Judith Félix, Beatriz Solo de Zaldívar, M Carmen Martínez-Cuesta, Noemí Ceprián, Teresa Requena, Mónica De la Fuente

Department of Genetics, Physiology and Microbiology (Animal Physiology Unit), Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. · pubmed

Paper

Abstract

Prematurely aged mice (PAM), characterized by an inadequate stress response, exhibit early immunosenescence and reduced lifespan compared with exceptional non-PAM (E-NPAM) of the same age. Lacticaseibacillus rhamnosus GG (LGG) has been proposed as a beneficial probiotic in healthy aging. This study aimed to evaluate the effects of LGG consumption over 2 and 4 weeks on behavioral parameters, peritoneal leukocyte function, and lifespan in adult female PAM.

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Research summary

Lacticaseibacillus rhamnosus GG consumption improves behavior, immune functions, and biological age markers in prematurely aged female mice. The study addresses the effects of a probiotic on biological aging markers, which is directly related to the mechanisms of aging and potential interventions for longevity.

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