Age and Inflammation: Insights on "Age Three Ways" from Midlife in the United States Study.

Dakota D Witzel, Aarti C Bhat, Jennifer E Graham-Engeland, David M Almeida

College of Education, Counseling, and Human Development, South Dakota State University, United States; Center for Healthy Aging, Penn State University, United States. Electronic address: [email protected] of Education, Counseling, and Human Development, South Dakota State University, United States; Center for Healthy Aging, Penn State University, United States. Electronic address: [email protected]. · pubmed

Paper

Abstract

Chronological age is a particularly well-known indicator of variability in systemic inflammation. Other pertinent aspects of age (or "age proxies") - subjective or epigenetic age - may offer nuanced information about age and inflammation associations. Using the Midlife in the United States Study, we explored how chronological, subjective, and epigenetic age were associated with inflammation. Further, we tested whether chronological age remained a unique predictor of inflammation after accounting for the variance of subjective and epigenetic age. Using an intersectionality framework, we also tested whether associations differed by race and gender.

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Research summary

Chronological, subjective, and epigenetic age are associated with inflammation, with a focus on their unique contributions and intersectionality factors. The paper is relevant as it explores different aspects of age and their relationship with inflammation, which could provide insights into the biological mechanisms of aging and potential interventions.

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