Unveiling two distinct osteolineage cell populations linked to age-related osteoporosis in adult mice through integrative single-cell analyses.

Bo Zhou, Hongwen Huang, Zhen Ding, Kaiwen Luo, Yangshan Chen, Yingying Han, Wei Pang, Wanze Tang, Litong Chen, Wenfei Jin, Guixing Ma, Huiling Cao

Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen, 518055, China.Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen, 518055, China. · pubmed

Paper

Abstract

The bone marrow microenvironment contains heterogeneous stromal cells, which are critical for bone remodeling and provide essential supportive roles for hematopoietic functions. Although the diversity of PDGFRα

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper identifies two distinct osteolineage cell populations associated with age-related osteoporosis in adult mice. This research is relevant as it explores cellular mechanisms linked to age-related bone degeneration, which is a significant aspect of aging and longevity.

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