Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors.

Liming Du, Maria Angelica Freitas-Cortez, Jingzhu Zhang, Yuanyuan Xue, Reshma T Veettil, Zhiyu Zhao, Sean J Morrison

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390. · pubmed

Paper

Abstract

In early postnatal and young adult bone marrow, Leptin receptor-expressing (LepR

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Research summary

The paper claims that inflammation in periarteriolar niches of aging bone marrow remodels the stromal microenvironment and depletes lymphoid progenitors. This research addresses the underlying changes in the bone marrow microenvironment associated with aging, which is relevant to understanding the mechanisms of aging and potential interventions.

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