Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage.

Jing Yang, Chun-Rui Zhang, Zi-Xuan Li, Yi-He Gao, Li Jiang, Jing Zhang, Peng-Yue Wang, Tong Liu

Puyang Medical College, Puyang, 457000, China. Electronic address: [email protected] Medical College, Puyang, 457000, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Myocardial aging, involving oxidative stress, mitochondrial dysfunction, and cellular senescence, is crucial to DOX - induced heart failure. DOX has dose - dependent cardiotoxicity. Sper a natural polyamine with antioxidant and anti - aging effects, remains unstudied in this context.

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Research summary

Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage. The paper addresses the role of oxidative stress and mitochondrial dysfunction in myocardial aging, which are key factors in the aging process and age-related diseases.

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