Salvianolic acid B protects against UVB-induced HaCaT cell senescence and skin aging through NRF2 activation and ROS scavenging.

Jia-Ming Sun, Yu-Xin Liu, Yi-Tung Tsai, Yang-Dan Liu, Chia-Kang Ho, Dong-Sheng Wen, Ting-Yu Tsai, Dan-Ning Zheng, Ya Gao, Yi-Fan Zhang, Li Yu

Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhi Zao Ju Road, Shanghai 200011, PR China. · pubmed

Paper

Abstract

Prolonged sunlight exposure can cause skin photoaging. The epidermis, the outermost layer of the skin, protects the body from the environment. This study explored the protective effect of salvianolic acid B (Sal-B), a bioactive compound from Salvia miltiorrhiza, against photoaging and examined its specific mechanism.

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Research summary

Salvianolic acid B protects HaCaT cells from UVB-induced senescence through NRF2 activation and ROS scavenging. The study addresses mechanisms of skin aging, which is a significant aspect of the broader context of aging and longevity research.

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