Reduced removal of waste products from energy metabolism takes center stage in human brain aging.

Silvia Mangia, Mauro DiNuzzo, Sara Ponticorvo, Gerald A Dienel, Kevin L Behar, Helene Benveniste, Fahmeed Hyder, Federico Giove, Suzana Herculano-Houzel, Ognen A Petroff, Lynn E Eberly, Pavel Filip, Shalom Michaeli, Douglas L Rothman

Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. [email protected] of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. [email protected]. · pubmed

Paper

Abstract

Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO

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Research summary

The paper claims that reduced removal of waste products from energy metabolism is a key factor in human brain aging. This research addresses a potential root cause of aging by exploring the mechanisms behind brain function decline, which is relevant to longevity studies.

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