The influence of age on cellular senescence in injured versus healthy muscle and its implications on rotator cuff injuries.

Kevin C Wang, Justin Lau, Steven M Garcia, Aboubacar Wague, Sankalp Sharma, Xuhui Liu, Brian T Feeley

Division of Orthopedics, Columbia University at Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address: [email protected] of Orthopedics, Columbia University at Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

Advanced age increases the prevalence of rotator cuff tears and affects the success of repair surgeries. Cellular senescence is proposed as a key mechanism behind these age-related differences, likely due to contribution of the senescence-associated secretory phenotype. This state is linked to various age-related diseases, including rotator cuff injuries.

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Research summary

The paper claims that cellular senescence contributes to age-related differences in rotator cuff injuries. This research addresses a mechanism linked to aging and its implications for age-related diseases, which is relevant to longevity studies.

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