CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults.

Alper Cevirgel, Martijn Vos, Elske Bijvank, Josine van Beek, Marieke van der Heiden, Anne-Marie Buisman, Debbie van Baarle

Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. · pubmed

Paper

Abstract

The T cell compartment undergoes significant age-related changes, contributing to the decline of the adaptive immune system and increasing the risk of suboptimal antibody responses to vaccines in older adults. To better understand the association between T cell phenotypes and vaccine responsiveness, we conducted an in-depth analysis of CD4+, CD8+, and γδ + T cells on VITAL cohort participants who are low or high responders to multiple vaccines (influenza, pneumococcal, and SARS-CoV-2).

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that specific T cell phenotypes are associated with vaccine responsiveness in older adults. This research is relevant as it addresses the age-related decline in immune function, which is a critical aspect of aging and longevity.

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