PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis.

Pengbo Chen, Bo Li, Zeyu Lu, Qingyin Xu, Huoliang Zheng, Shengdan Jiang, Leisheng Jiang, Xinfeng Zheng

Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. · pubmed

Paper

Abstract

It has been reported that loss of PCBP2 led to increased reactive oxygen species (ROS) production and accelerated cell aging. Knockdown of PCBP2 in HCT116 cells leads to significant downregulation of fibroblast growth factor 2 (FGF2). Here, we tried to elucidate the intrinsic factors and potential mechanisms of bone marrow mesenchymal stromal cells (BMSCs) aging from the interactions among PCBP2, ROS, and FGF2.

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Research summary

The paper claims that PCBP2 regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis. This research is relevant as it explores intrinsic factors contributing to cellular aging, which could provide insights into the mechanisms of aging and potential interventions.

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