Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration.

Jinru Tang, Jingya Li, Zeyu Hou, Rong He, Bingzhi Li, Jiajing Gong, Yuhang Xie, Wanrong Meng, Yunkun Liu, Takehito Ouchi, Longjiang Li, Bo Li

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. · pubmed

Paper

Abstract

Age-related alveolar bone resorption poses a major dental health challenge, yet its mechanisms and treatments are poorly understood. This study investigates the impact of dasatinib and quercetin (D + Q) treatment on senescent cells (SnCs), senescence-associated secretory phenotype (SASP), and neutrophil infiltration in aged alveolar bone, aiming to develop new strategies for combating age-related bone resorption.

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Research summary

Dasatinib and quercetin treatment reduces senescent cell accumulation and inflammation in aged alveolar bone. This study addresses mechanisms of aging by targeting senescence and inflammation, which are key contributors to age-related diseases.

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