SIRT3 suppresses vascular endothelial senescence via DHRS2 and contributes to the anti-vascular aging effect of Bazi Bushen capsule.

Yuan Zhao, Chunmei Zhang, Chen Zhang, Xuehui Zheng, Yan Qi, Binghui Kong, Yunlong Hou, Yun Ti, Peili Bu

State Key Laboratory for Innovation and Transformation of Luobing Theory, China; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, China; Department of Cardiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China.State Key Laboratory for Innovation and Transformation of Luobing Theory, China; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, China; Department of Cardiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China. · pubmed

Paper

Abstract

Vascular and endothelial aging are significant causes of chronic diseases among the elderly. This study investigated the specific mechanism by which sirtuin 3 (SIRT3) regulates vascular endothelial senescence and the beneficial role of Bazi Bushen capsule (BZBS) in preventing vascular aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

SIRT3 regulates vascular endothelial senescence through DHRS2 and is involved in the anti-vascular aging effects of Bazi Bushen capsule. This paper addresses the mechanisms underlying vascular aging, which is a root cause of age-related diseases, thus contributing to the understanding of longevity and potential interventions.

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