Relationship of Klotho with cognition and dementia: A systematic review and meta-analysis.

Yu Liu, Junfei Huang, Benhong Xu

School of Public Health, Zunyi Medical University, China; Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, China.School of Public Health, Zunyi Medical University, China; Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, China. · pubmed

Paper

Abstract

The protein Klotho, known for its connection to longevity, has attracted growing interest among researchers for its positive effects on the cognitive function and dementia during aging. Nevertheless, the precise correlation between levels of Klotho and cognitive function and dementia remains inadequately elucidated, with conflicting conclusions arising from different studies.

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Research summary

The paper investigates the relationship between Klotho levels and cognitive function/dementia. The focus on Klotho, a protein associated with longevity, suggests potential insights into mechanisms of aging and cognitive decline, although the findings may not significantly advance the field.

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