Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog.

Aurora D Foster, Chad R Straight, Philip C Woods, Christopher Lee, Jane A Kent, Stuart R Chipkin, Edward P Debold, Mark S Miller

Department of Kinesiology, University of Massachusetts, Amherst, MA, USA.Department of Kinesiology, University of Massachusetts, Amherst, MA, USA. · pubmed

Paper

Abstract

Skeletal muscle fatigue occurs, in part, from accumulation of hydrogen (H

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Research summary

The paper claims that alterations in contractile function in aged human skeletal muscle due to phosphate and acidosis can be partially reversed with an ATP analog. This research addresses mechanisms underlying muscle function decline with aging, which is directly related to the biological processes of aging and potential interventions for age-related muscle deterioration.

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