Protein epigenetic scores and overall mortality in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA).

Thaís Lopes De Oliveira, Arianna March, Jonathan K L Mak, Nancy L Pedersen, Sara Hägg

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12a, 17177, Stockholm, Sweden. [email protected] of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12a, 17177, Stockholm, Sweden. [email protected]. · pubmed

Paper

Abstract

DNA methylation (DNAm) has a functional role in gene regulation, and it has been used to estimate various human characteristics. Variation in DNAm is associated with aging and variability of the proteome. Therefore, understanding the relationship between blood circulating proteins, aging, and mortality is critical to identify disease-causing pathways. We aimed to estimate the association between protein epigenetic scores (EpiScores) and overall mortality in the Swedish Adoption/Twin Study of Aging (SATSA).

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Research summary

The paper claims that protein epigenetic scores (EpiScores) are associated with overall mortality in aging populations. This research is relevant as it explores the relationship between biological markers and mortality, potentially shedding light on underlying mechanisms of aging and longevity.

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