Maimendong decoction modulates the PINK1/Parkin signaling pathway alleviates type 2 alveolar epithelial cells senescence and enhances mitochondrial autophagy to offer potential therapeutic effects for idiopathic pulmonary fibrosis.

Yuhe Zhou, Wen Su, Mengzhen Xu, Aijun Zhang, Shaoli Li, Hong Guo, Kai Gong, Kaihui Lu, Xin Yu, Jiang Zhu, Qingjun Zhu, Chuanguo Liu

Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected] Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Maimendong decoction (MMDD) originates from the ancient Chinese medical text Synopsis of the Golden Chamber and is a well-established remedy for treating lung diseases. It has demonstrated efficacy in the long-term clinical management of idiopathic pulmonary fibrosis (IPF); however, its underlying mechanisms remain unclear.

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Research summary

Maimendong decoction modulates the PINK1/Parkin signaling pathway to alleviate senescence in type 2 alveolar epithelial cells. The paper is relevant as it explores mechanisms that may address cellular senescence and mitochondrial dysfunction, which are key factors in aging and age-related diseases.

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