17β-estradiol delays cardiac aging through suppressing the methylation of Beclin1 in a murine model.

Lili Ye, Ruiyan Wang, Jun Zhao, Jingrong Chen, Feng Wang

Department of Cardiovascular medicine, Department of General practice, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510700, PR China.Department of Cardiovascular medicine, Department of General practice, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510700, PR China. · pubmed

Paper

Abstract

Cardiac endogenous senescence will gradually change and aggravate with age. Recent research showed that 17β-estradiol (17β-E2), an estrogen with numerous biological activities including the prevention of vascular senescence. However, how 17β-E2 against cardiac aging is still unknown. This work addressed the underlying mechanism with regard to Beclin1 and autophagy activity to better understand the anti-senescent effect of 17β-E2 on a well-established animal model of cardiac aging.

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Research summary

17β-estradiol delays cardiac aging by suppressing the methylation of Beclin1, enhancing autophagy. This research addresses a potential mechanism underlying cardiac aging, which is directly related to the biological processes of aging and longevity.

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