Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases.

A G M Sofi Uddin Mahamud, Ishtiak Ahammed Tanvir, Md Ehsanul Kabir, Ismam Samonty, Md Anamul Hasan Chowdhury, Md Ashikur Rahman

Department of Microbiology, University of Georgia, Athens, GA, 30602, USA. [email protected] of Microbiology, University of Georgia, Athens, GA, 30602, USA. [email protected]. · pubmed

Paper

Abstract

As unhealthy aging continues to rise globally, there is a pressing need for effective strategies to promote healthy aging, extend health span, and address aging-related complications. Gerobiotics, an emerging concept in geroscience, offers a novel approach to repurposing selective probiotics, postbiotics, and parabiotics to modulate key aging processes and enhance systemic health. This review explores recent advancements in gerobiotics research, focusing on their role in targeting aging hallmarks, regulating longevity-associated pathways, and reducing risks of multiple age-related chronic conditions. Despite their promise, significant challenges remain, including optimizing formulations, ensuring safety and efficacy across diverse populations, and achieving successful clinical translation. Addressing these gaps through rigorous research, well-designed clinical trials, and advanced biotechnologies can establish gerobiotics as a transformative intervention for healthy aging and chronic disease prevention.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Gerobiotics may modulate key aging processes and enhance systemic health through the repurposing of probiotics. The paper is relevant as it addresses potential interventions targeting the root causes of aging and chronic diseases, rather than merely treating symptoms.

Author of this paper? Send a correction.