Metformin alleviates auditory cell senescence by mitophagy induction.

Sung Il Cho, Eu-Ri Jo, Hee Sun Jang

Department of Otolaryngology-Head and Neck Surgery, Chosun University College of Medicine, Gwangju, Republic of Korea. Electronic address: [email protected] of Otolaryngology-Head and Neck Surgery, Chosun University College of Medicine, Gwangju, Republic of Korea. Electronic address: [email protected]. · pubmed

Paper

Abstract

Age-related hearing loss is the most common type of hearing loss in older adults. However, its underlying cellular mechanism is still unclear. Impaired mitochondrial function is a hallmark of various age-related pathologies. To maintain mitochondrial function in senescent cells, mitophagy is a crucial process for dysfunctional mitochondria turnover. Metformin has been reported to induce mitophagy. This study aimed to investigate the effect of metformin on preventing senescence in auditory cells. Low-dose H

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Metformin induces mitophagy to alleviate auditory cell senescence. The study addresses a potential mechanism underlying age-related hearing loss, which is a significant aspect of aging and longevity research.

Author of this paper? Send a correction.