Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study.

Mika Kivimäki, Philipp Frank, Jaana Pentti, Markus Jokela, Solja T Nyberg, Acer Blake, Joni V Lindbohm, Hamilton Se-Hwee Oh, Archana Singh-Manoux, Tony Wyss-Coray, Linda Partridge

UCL Brain Sciences, University College London, London, UK; Clinicum, University of Helsinki, Helsinki, Finland. Electronic address: [email protected] Brain Sciences, University College London, London, UK; Clinicum, University of Helsinki, Helsinki, Finland. Electronic address: [email protected]. · pubmed

Paper

Abstract

Biological ageing is known to vary among different organs within an individual, but the extent to which advanced ageing of specific organs increases the risk of age-related diseases in the same and other organs remains poorly understood.

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Research summary

The paper claims that advanced ageing of specific organs is associated with an increased risk of age-related diseases. This research is relevant as it explores the biological mechanisms of aging and their implications for age-related diseases, contributing to the understanding of longevity.

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