Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice.

Marisa Ferreira-Marques, Sara Carmo-Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López-Otín, Luís Pereira de Almeida, Célia A Aveleira, Cláudia Cavadas

CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. · pubmed

Paper

Abstract

The hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during aging, we investigated if reestablishment of NPY levels mitigate aging phenotype, using a mouse model of premature aging - Zmpste24

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Research summary

Restoring neuropeptide Y levels in the hypothalamus can mitigate the aging phenotype in a mouse model. The research addresses a potential root cause of aging by exploring the role of neuropeptide Y in regulating aging processes, which is directly relevant to longevity research.

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