Secretome from HMGB1 Box A-over-expressing Adipose-derived Stem Cells Shows Potential for Skin Rejuvenation by Senescence Reversal in PM2.5-induced Senescence Cells

Zin Zin Ei, Apiwat Mutirangura, Pithi Chanvorachote

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. · pubmed

Paper

Abstract

Exposure to particulate matter 2.5 (PM2.5) can lead to cellular senescence by generating reactive oxygen species (ROS). Box A, a DNA-binding domain found in HMGB1, is known for its ability to counteract aging characteristics. This study explored whether BoxA-induced adipose-derived stem cells secretome (BoxA-SC) can reverse senescence in DP and HWPc cells.

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Research summary

The paper claims that the secretome from HMGB1 Box A-over-expressing adipose-derived stem cells can reverse cellular senescence induced by PM2.5 exposure. This research is relevant as it addresses mechanisms that may counteract aging processes, specifically cellular senescence, which is a significant contributor to age-related decline.

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