Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle.

Elena Alcalde-Estévez, Ariadna Moreno-Piedra, Ana Asenjo-Bueno, María Martos-Elvira, Mariano de la Serna-Soto, Marta Ruiz-Ortega, Gemma Olmos, Susana López-Ongil, María P Ruiz-Torres

University of Alcalá, Faculty of Medicine and Health Sciences, Department of Systems Biology, Alcalá de Henares, Madrid 28871, Spain.University of Alcalá, Faculty of Medicine and Health Sciences, Department of Systems Biology, Alcalá de Henares, Madrid 28871, Spain. · pubmed

Paper

Abstract

The association between aging-related hyperphosphatemia and sarcopenia has been documented, and evidence suggests that inflammaging is involved in the manifestation of sarcopenia. The present study investigates whether hyperphosphatemia triggers inflammation, thereby inducing the appearance of sarcopenia along with the cytokines involved in these processes.

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Research summary

The paper claims that aging-related hyperphosphatemia triggers inflammation that contributes to sarcopenia through the reduction of IL-15 expression in skeletal muscle. This research addresses a potential mechanism linking metabolic dysregulation and inflammation to age-related muscle loss, which is relevant to understanding and potentially mitigating aspects of aging.

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