Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice.

Maira Rossi, Lucrezia Zuccarelli, Lorenza Brocca, Cristiana Sazzi, Clarissa Gissi, Paola Rossi, Bruno Grassi, Simone Porcelli, Roberto Bottinelli, Maria Antonietta Pellegrino

Department of Molecular Medicine, University of Pavia, Pavia, Italy. · pubmed

Paper

Abstract

In ageing, denervation and neuromuscular junction (NMJ) instability occur alongside mitochondrial alterations and redox unbalance, potentially playing a significant role in the process. Moreover, the synthetic pathway was shown to be critical for proper innervation and NMJ stability. Nitric oxide (NO) modulates redox status, mitochondrial function and the synthetic pathway. Its bioavailability declines with age. We hypothesize that nitrate supplementation could counteract age-related neuromuscular alterations. We compared young (Y) (7 months old), old (O) (24 months old) and old mice supplemented daily with 1.5 mm inorganic NaNO

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Research summary

Dietary nitrate supplementation can counteract age-related neuromuscular alterations in mice. The study addresses the underlying mechanisms of aging by exploring how nitrate can improve neuromuscular junction stability, which is directly related to age-related decline in function.

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