Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults.

Anna E Bortnick, Thomas R Austin, Emily Hamerton, Valborg Gudmundsdottir, Valur Emilsson, Lori L Jennings, Vilmundur Gudnason, David S Owens, Daniele Massera, Line Dufresne, Ta-Yu Yang, James C Engert, George Thanassoulis, Russell P Tracy, Robert E Gerszten, Bruce M Psaty, Jorge R Kizer

Department of Medicine, Divisions of Cardiology and Geriatrics Montefiore Medical Center and Albert Einstein College of Medicine Bronx NY. · pubmed

Paper

Abstract

Calcific aortic valve disease (CAVD), and ensuing severe aortic stenosis (AS), is the foremost valvular disorder of aging, yet preventive therapies are lacking. A better understanding of the molecular underpinnings of aortic valve calcification (AVC) is necessary to develop pharmacologic interventions.

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Research summary

The paper investigates the molecular mechanisms underlying calcific aortic valve disease to inform potential pharmacologic interventions. This research is relevant as it seeks to understand and address a specific age-related disease, contributing to the broader goal of improving healthspan and longevity.

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