A polyepigenetic glucocorticoid exposure score and HPA axis-related DNA methylation are associated with gestational epigenetic aging.

Allison A Appleton

Department of Epidemiology and Biostatistics, University at Albany College of Integrated Health Sciences, Rensselaer, NY, USA.Department of Epidemiology and Biostatistics, University at Albany College of Integrated Health Sciences, Rensselaer, NY, USA. · pubmed

Paper

Abstract

Gestational epigenetic aging (GEA) is a novel approach for characterizing associations between prenatal exposures and postnatal risks. Psychosocial adversity in pregnancy may influence GEA, but the molecular mechanisms are not well understood. DNA methylation to glucocorticoid regulation and hypothalamic-pituitary-adrenal (HPA) axis genes are implicated but have not been fully examined in association with GEA. This study investigated whether a polyepigenetic glucocorticoid exposure score (PGES) and HPA axis gene (

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Research summary

The paper claims that a polyepigenetic glucocorticoid exposure score and HPA axis-related DNA methylation are associated with gestational epigenetic aging. This research explores the molecular mechanisms linking prenatal exposures to aging processes, which is relevant to understanding the root causes of aging.

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