Age-dependent reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia.

Bonn Lee, Shiraz Ahmad, Charlotte E Edling, Christopher L-H Huang, Fiona E N LeBeau, Kamalan Jeevaratnam

School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK. · pubmed

Paper

Abstract

Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose the myocardial conducting system to arrhythmias. However, little is known about age-related changes in the electrophysiology of murine SG. We investigated alterations in the electrophysiological properties of SG with aging. The loose patch clamp technique was adapted to SG tissue to investigate the voltage-gated ionic currents in its neuronal cells. We compared SG and ventricular cells from young (4 months) and aged (13 months) C57BL/6J mice to explore age-related alterations in their voltage-gated ionic currents (n > 30 patches, eight mice in each group). We observed that the voltage-gated inward sodium current (peak I

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Research summary

The paper claims that aging leads to a reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia. This research is relevant as it investigates age-related electrophysiological changes that could contribute to understanding the mechanisms of aging and potential interventions for age-related diseases.

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