Identification of the enzymatic cleavage relationship between anti-aging protein α-Klotho and Alzheimer's disease biomarker BACE1.

Xiang Gao, Zuoli Sun, Jia Hu, Yuhong Li, Qi Deng, Rena Li

Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. · pubmed

Paper

Abstract

The α-Klotho is known to be involved in longevity and various age-related diseases, including cognitive impairment. BACE1, an important enzyme associated with the pathological process of Alzheimer's disease (AD), serves as a biomarker for predicting changes in cognitive function. Although both proteins are closely linked to age-related cognitive function, the mechanism of their interaction remains unclear.

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Research summary

The paper claims to identify the enzymatic cleavage relationship between α-Klotho and BACE1, suggesting a potential interaction that could influence cognitive function in aging. This research is relevant as it explores the interaction between proteins associated with aging and cognitive decline, which may contribute to understanding the mechanisms underlying age-related diseases.

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